دانلود مقاله Understanding how prolyl-4-hydroxylase structure steers a ferryl oxidant toward scission of a strong C-H bond

دسته بندی : مقاله انگلیسی فایل : pdf تعداد صفحه :17 زبان مقاله : انگلیسی  شاخه مقاله : شیمی مناسب دانشجویان و علاقه مندان مقدمه : Prolyl-4-hydroxylase (P4H) is a nonheme iron hydroxylase that regio- and stereospecifically hydroxylates proline residues in a peptide chain into R-4-hydroxyproline, which is essential for collagen crosslinking purposes in the human body. Surprisingly, in P4H a strong aliphatic C–H bond is activated, while thermodynamically much weaker aliphatic ...